HIF2A as a prognostic and clinical therapeutic target in ovarian clear cell carcinoma.
Ovarian clear cell carcinoma (CCC) is an aggressive subtype of ovarian cancer that is resistant to conventional chemotherapy, resulting in poor prognosis. CCC develops from endometriosis, which exposes tumor cells …
Metabolism-Regulating Microspheres: Design Principles, Therapeutic Applications Across Multisystem Diseases, and Future Perspectives.
Metabolism-regulating microspheres have evolved from conventional drug carriers into active platforms capable of spatiotemporally reprogramming pathological metabolic networks. Chronic diseases are increasingly understood to be driven by metabolic dysregulation, highlighting …
CXCL12 promotes EMT-mediated malignant transformation of endometriosis-associated ovarian cancer via PI3K/Akt signaling: An integrated transcriptomic and clinical study.
Endometriosis-associated ovarian cancer (EAOC) is a distinct form of epithelial ovarian cancer that arises from the malignant transformation of benign endometriotic lesions. While epithelial-mesenchymal transition (EMT) is acknowledged as a …
En Bloc Hysterectomy with segmental bowel resection by NOSE-procedure: Surgical Management of Ovarian Cancer in context of Deep Infiltrating Endometriosis.
To show the safety of en bloc hysterectomy with segmental bowel resection utilizing the NOSE-technique in the management of ovarian cancer and deep infiltrating endometriosis (DIE).
Significance of Follicle-Stimulating Hormone Receptor Gene Single-Nucleotide Polymorphism rs6165/rs6166 Analysis for Infertility-Associated Ovarian Disease Susceptibility Prediction and Optimized Individualized Ovulation Induction/Ovarian Stimulation.
Follicle-stimulating hormone receptor (FSHR) is expressed on the plasma membrane of granulosa cells in the ovarian follicles. FSHR is involved in the development and maturation of Graafian follicles, along with …
Transcriptomic landscape of coexisting ovarian clear cell carcinoma and endometriosis: Insights into malignant transformation.
This study investigateted the malignant transformation of endometriosis (EMS) into ovarian clear cell carcinoma (OCCC) using spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) integration. Tissues with coexisting EMS and OCCC …
Chinese Researchers Develop Prognostic Model Using Molecular Signatures to Predict Outcomes in Endometriosis-Associated Ovarian Cancer - geneonline.com
Chinese Researchers Develop Prognostic Model Using Molecular Signatures to Predict Outcomes in Endometriosis-Associated Ovarian Cancer geneonline.com