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Neutrophil-To-Lymphocyte and Platelet-To-Lymphocyte Ratios in atypical endometriosis and in Endometriosis-Associated ovarian-Cancer.

Atypical endometriosis (AE) is a histologically distinct entity considered a potential precursor to Endometriosis-Associated Ovarian Cancer (EAOC). Preoperative diagnosis is challenging as imaging often fails to distinguish AE from benign …

MicroRNA Expression Profile in Endometriosis and Endometriosis-Associated Ovarian Cancer-Systematic Review.

Endometriosis-associated ovarian cancer comprises a special group of ovarian cancers that most probably originate from endometriosis foci. Several in vitro studies have shown that microRNA (miRNA) plays an important role …

Tumor-intrinsic B4GALNT3 expression drives a protective immune microenvironment in endometriosis-associated ovarian cancer.

Although endometriosis-associated ovarian cancer (EAOC) is considered a separate clinical entity, no specific prognostic biomarkers aid in its management. This has, therefore, been among the factors hindering the development of …

Rethinking estrogen receptor β in EAOC: a synergistic modulator in a genomically informed landscape.

CXCL12 promotes EMT-mediated malignant transformation of endometriosis-associated ovarian cancer via PI3K/Akt signaling: An integrated transcriptomic and clinical study.

Endometriosis-associated ovarian cancer (EAOC) is a distinct form of epithelial ovarian cancer that arises from the malignant transformation of benign endometriotic lesions. While epithelial-mesenchymal transition (EMT) is acknowledged as a …

Transcriptomic landscape of coexisting ovarian clear cell carcinoma and endometriosis: Insights into malignant transformation.

This study investigateted the malignant transformation of endometriosis (EMS) into ovarian clear cell carcinoma (OCCC) using spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) integration. Tissues with coexisting EMS and OCCC …

In Situ Characterization and Deep Profiling of Engineered Multispecific Nanoparticle Metabolite Coronas for Precise Serum Diagnostics.

Upon exposure to biofluids, engineered nanoparticles (NPs) spontaneously form reproducible biomolecular coronas via selective diverse biomolecule adsorption. The corona characterization of metabolites poses greater analytical challenges than proteins due to …

Therapeutic targeting of interleukin-17C signaling in carcinogenesis of endometriosis.

Endometriosis-associated ovarian carcinoma (EAOC) predominantly arises from the malignant transformation of endometriomas, yet the mechanism is incompletely defined. Spatial transcriptomic analysis of human specimens of normal endometrium, endometriomas, and EAOC …

TCGA molecular subtypes in endometriosis-associated ovarian cancer: a systematic review and meta-analysis.

Endometriosis-associated ovarian cancer (EAOC) mainly includes endometrioid ovarian cancer (ENOC) and clear cell ovarian cancer (CCOC). The Cancer Genome Atlas (TCGA) revealed four molecular subtypes of endometrial cancer (EC) in …

Reframing Endometriosis: Interplay of NETs, Macrophages, and Lymphocytes at the Crossroads of Disease Progression, Infertility, and Malignant Transformation.

Endometriosis (ENDO) is a painful, chronic gynecological disease widely affecting women globally. While traditionally classified as a hormonal disorder, ENDO is now increasingly recognized as a multifaceted immune-mediated syndrome driven …