Latest Articles

Endometriosis beyond the pelvis: Insights from atypical presentations leading to diagnostic delays.

The evolution of endometriosis research models: a paradigm shift from immortalized cell lines to organoids†.

Endometriosis is a complex condition affecting 10% of reproductive-age women worldwide, yet its study has long been hindered by the shortcomings of traditional research models. This review aims to propose …

Cholesterol granuloma forming the solid components within an endometrioma showing intense FDG uptake, mimicking malignancy: A case report.

A mural solid component (SC) within an endometrioma (ovarian endometriotic cyst), demonstrating internal vascularity or increased fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET), is considered a characteristic finding suggestive …

CXCL12 promotes EMT-mediated malignant transformation of endometriosis-associated ovarian cancer via PI3K/Akt signaling: An integrated transcriptomic and clinical study.

Endometriosis-associated ovarian cancer (EAOC) is a distinct form of epithelial ovarian cancer that arises from the malignant transformation of benign endometriotic lesions. While epithelial-mesenchymal transition (EMT) is acknowledged as a …

Plasma extracellular vesicle modulate immune cell transcriptional responses following acute myocardial infarction.

Plasma extracellular vesicles (EVs) increase during acute myocardial infarction (MI), correlate with myocardial injury, and mobilize immune cells from the spleen to the circulation. These cells are transcriptionally activated even …

The role of insulin-like growth factor binding proteins in TGF-β1-induced fibroblast-myofibroblast transition during endometriosis fibrosis.

Fibrosis is a defining feature of endometriosis (EMS). Our previous single-cell RNA sequencing (scRNA-seq) revealed myofibroblasts (MFBs) as the predominant cells in ectopic endometrium (ECE), mainly derived from fibroblast-to-myofibroblast transition …

Active surveillance of an endometriosis-related, hormone-responsive pelvic adenosarcoma during pregnancy: A case report.

Extrauterine adenosarcomas are rare gynecologic malignancies that can arise within foci of pelvic endometriosis. They are often hormone mediated and thus are challenging to treat during pregnancy.

Transcriptomic landscape of coexisting ovarian clear cell carcinoma and endometriosis: Insights into malignant transformation.

This study investigateted the malignant transformation of endometriosis (EMS) into ovarian clear cell carcinoma (OCCC) using spatial transcriptomics and single-cell RNA sequencing (scRNA-seq) integration. Tissues with coexisting EMS and OCCC …

Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio and endometriosis: a population-based study.

The gamma-glutamyl transferase (GGT) to high-density lipoprotein (HDL) ratio (GGT/HDL) has recently emerged as a potential biomarker for metabolic and liver diseases. This study aimed to investigate the association between …

FTIR Spectroscopy Combined with Machine Learning Reveals Molecular Signatures Distinguishing three Phenotypes of Endometriosis.

Endometriosis is a chronic inflammatory disorder in which endometrial tissue grows outside the uterus, leading to pelvic pain and infertility. It remains a major challenge in women's health due to …