Endometriosis is a prevalent, estrogen-dependent, inflammatory disease that impairs fertility via hormonal dysregulation, immune dysfunction, oxidative stress/ferroptosis, genetic and epigenetic alterations, and microbiome imbalance. We summarize multi-omics insights and clinical …
Endometriosis (E) is multifactorial disease affecting around 10% of women worldwide. The association between E and infertility is clinically well recognized. For E patients to achieve a successful pregnancy, assisted …
We aimed to examine abnormal oxidative lipid levels and their related mechanisms in EM-associated infertility. Through liquid chromatography tandem mass spectrometry analysis, decreased levels of epoxyeicosatrienoic acids (EETs), which have …
Endometriosis poses significant challenges for women of reproductive age, particularly due to its impact on ovarian reserve and fertility. In addition to endometriosis-associated infertility contributing to diminished ovarian reserve by …
Endometriosis-Associated Infertility: Multi-Omics Insights into Pathogenesis and Precision Therapeutics Frontiers
Endometriosis, a chronic estrogen-dependent disorder defined by ectopic endometrial-like tissue growth, causes pelvic pain and infertility in reproductive-age women. Despite its prevalence, the underlying mechanisms driving lesion persistence and reproductive …
Endometriosis markedly compromises female fertility, and although endometrial dysfunction likely plays a role in this pathology, its precise mechanistic contributions remain poorly understood. This study aims to investigate the decidualization …
Women with endometriosis-associated infertility are more likely to become pregnant, study reveals News-Medical
Couple infertility poses a health challenge, prompting research into its multifaceted aetiology. Non-coding RNA (ncRNA) expression has emerged as a candidate for elucidating couple infertility. This review explores the roles …
Endometriosis is a chronic gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. A common feature of this pathology is the impaired decidualization of endometrial stromal …