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Metabolic reprogramming in endometriosis: mechanisms and therapeutic prospects.

Endometriosis (EMS) is an estrogen-dependent chronic inflammatory disorder for which metabolic reprogramming has emerged as a central pathological feature. Driven by genetic, epigenetic, and microenvironmental stressors, ectopic endometrial cells undergo …

Published: May 3, 2026, midnight
Prenatal bisphenol A exposure reprograms SF1-lactylation pathways to promote endometriosis susceptibility.

Endometriosis is an estrogen-dependent disorder influenced by dysregulated steroidogenesis, oxidative stress, and inflammation. Bisphenol A (BPA), a common endocrine disruptor, has been associated with reproductive dysfunction, but its developmental impacts …

Published: April 4, 2026, midnight
The role of Fusobacterium nucleatum in the pathogenesis of endometriosis: A microbial and microenvironmental perspective.

Endometriosis is a chronic, inflammatory gynecological condition characterized by the ectopic growth of endometrial-like tissue, with an unclear etiology and limited treatment efficacy. Recent studies implicate the oral and gut …

Published: Feb. 4, 2026, midnight
Endometriosis and the Hallmarks of Cancer.

Endometriosis (EMS) is a non-cancerous invasive condition where tissue resembling the lining of the uterus is found outside of the uterine cavity. Endometriotic lesions have been found in nearly every …

Published: Dec. 23, 2025, midnight
Lactate-mediated immune suppression and MDSC expansion in endometriosis: Mechanisms and nanoparticle-targeted therapies.

Endometriosis, a chronic gynecological disorder characterized by the ectopic growth of endometrial-like tissue, is associated with severe pelvic pain, infertility, and profound immune dysregulation. Despite advances in hormonal therapy and …

Published: Nov. 1, 2025, midnight
Identification and validation of lactate-related gene signatures in endometriosis for clinical evaluation and immune characterization by WGCNA and machine learning.

Endometriosis is a common benign gynecologic disease in women of reproductive age, and its manifestations remarkably decrease quality of life. Lactate, as a metabolite, exerts prominent effects across a wide …

Published: Oct. 7, 2025, midnight
Decreased Glycolysis due to LDHA m6A methylation in Endometrium of endometriosis impairs its decidualization and contributes to related infertility.

Endometriosis-related infertility is a prevalent reproductive health concern of global significance. Functional abnormalities of the endometrium are increasingly recognized as a pivotal contributor to infertility in affected individuals. In the …

Published: Sept. 26, 2025, midnight
Identification and Validation of Lactate-related gene signatures in endometriosis for clinical valuation and immune characterization by WGCNA and machine learning - Frontiers

Identification and Validation of Lactate-related gene signatures in endometriosis for clinical valuation and immune characterization by WGCNA and machine learning Frontiers

Published: Sept. 16, 2025, 6:06 p.m.
Lactate-Induced M2 Macrophages Boost Endometrial Cancer Progression - BIOENGINEER.ORG

Lactate-Induced M2 Macrophages Boost Endometrial Cancer Progression BIOENGINEER.ORG

Published: Aug. 29, 2025, 10:40 p.m.
VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline - 2 Minute Medicine

VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline 2 Minute Medicine

Published: July 2, 2025, 7:18 p.m.
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