Endometriosis (EMS) is a chronic inflammatory disorder affecting ~10% of reproductive-age women, with increasing evidence implicating the microbiome in its pathogenesis through immunomodulation and estrogen metabolism. This study investigated microbiome …
Current models of endometriosis (EMs) still have limitations in replicating the key pathological features of human EMs, particularly the cyclic bleeding associated with ectopic lesions. To address this gap, this …
Uterine pain associated with labor, dysmenorrhea, or endometriosis is often driven by inflammation, which enhances nociceptive signaling and contributes to hyperalgesia. Although nonsteroidal anti-inflammatory drugs (NSAIDs) and glucocorticoids are commonly …
Intravascular adenomyomatosis (IA), characterised by endometrial-type glands or stroma embedded within smooth muscle tissue inside myometrial vessels, is a rare variant within the spectrum of uterine intravenous leiomyomatosis (IVL).
Around 18% to 33% of couples with infertility present with tubal occlusion (blocked or damaged fallopian tubes) or hydrosalpinx (fluid-filled tubes). Diagnostic laparoscopy (keyhole surgery) with chromopertubation (methylene blue dye …
Endometriosis (EMs) is a common cause of ovarian dysfunction and infertility, closely linked to iron overload-induced oxidative stress and ferroptosis. While electroacupuncture (EA) has shown promise in treating reproductive disorders, …
Endometriosis (EMS) is an estrogen-dependent chronic inflammatory disorder for which metabolic reprogramming has emerged as a central pathological feature. Driven by genetic, epigenetic, and microenvironmental stressors, ectopic endometrial cells undergo …
Estradiol (E2), a sex steroid hormone molecule, plays a key role in regulating the actin and shape dynamics of cells in a multitude of normal and pathophysiological conditions. While cytoskeletal …
Endometriosis-associated ovarian cancer (EAOC) is a rare subtype of ovarian cancer arising from the malignant transformation of endometriosis (EMS). Despite growing clinical awareness, its underlying pathogenic mechanisms are not fully …
Adenomyosis frequently coexists with endometriosis and shares overlapping symptoms; however, the symptom burden of isolated adenomyosis remains insufficiently defined. The aim of this study was to compare the severity and …