The likelihood of a successful pregnancy is influenced by a set of variables that influence endometrial receptivity, including hormonal, genetic, metabolic, age, lifestyle, and immunological factors. Among these, the endometrial …
The extracellular matrix (ECM) critically influences cell behavior, yet its properties in human endometrial lesions (HEL) and human uterine fibromas (HUF) are not well characterized. This study aimed to characterize …
The AFF2 gene encodes a protein involved in transcriptional regulation and chromatin remodeling. While primarily associated with Fragile X syndrome, AFF2 fusions have recently been identified in certain malignancies, mostly …
Endometriosis is a gynecological disorder predominantly affecting women of reproductive age and is considered a potential risk factor for the development of endometrial cancer. However, the molecular mechanisms underlying the …
Endometriosis affects a substantial number of women of reproductive age, yet current diagnostic methods rely on invasive procedures. To address this limitation, we investigated THBS1 as a potential biomarker and …
Small cell neuroendocrine carcinoma of the cervix (SCNEC) is a rare and highly aggressive malignancy with a poor prognosis. We report the case of a 36-year-old nulliparous woman with a …
Endometriosis is a common disease among women of childbearing age, and endoplasmic reticulum stress (ERS), a response involved in regulating protein homeostasis, has been linked to its pathogenesis. To identify …
Background: Desmoid tumors (DTs) are rare, locally aggressive soft-tissue neoplasms that often affect women of reproductive age. Pregnancy and prior abdominal surgery or trauma have been associated with tumor development …
Navigating Tumour Microenvironment in Endometrial Carcinoma: A Comprehensive Review Integrating Immunohistochemistry, Single-cell RNA-sequencing and Spatial Transcriptomics Frontiers
Female infertility, affecting millions worldwide, involves complex molecular mechanisms such as chronic inflammation, impaired cellular death, and protein regulation. This study explores how the cytokine IL-6, the autophagy marker LC3, …