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The dual nature of immunotherapy in female reproductive disorders: immune homeostasis and clinical challenges.

The female reproductive system (FRS) exhibits unique immunological characteristics, balancing defense against pathogens with tolerance to sperm and semi-allogeneic embryos. Key players include decidual natural killer (dNK) cells, immune checkpoint …

Published: Oct. 2, 2025, midnight
Circulating microRNAs and Endometriosis: A Comprehensive Analysis and Validation of Identified Biomarkers in the Indian Population.

Endometriosis is a prevalent condition where tissue similar to the uterine lining grows outside the uterus, causing pain and infertility. Diagnosing endometriosis typically requires invasive procedures like laparoscopy. MicroRNAs (miRNAs) …

Published: Oct. 1, 2025, midnight
Evaluating the diagnostic potential of CA-125 and miRNA levels in endometriosis: A narrative review.

Endometriosis, a common and complex gynecologic disorder, continues to pose a challenge to clinicians in diagnosis process due to its complexity. The aim of this review was to examine cancer …

Published: Oct. 1, 2025, midnight
Ovario-protective effect of intra-ovarian injection of platelet rich plasma (PRP) after laparoscopic cystectomy of ovarian endometrioma: a randomized control trial.

This study aimed to evaluate the effectiveness of Platelet-Rich Plasma (PRP) in preserving ovarian reserve in patients with endometriosis who underwent laparoscopic cystectomy.

Published: Oct. 1, 2025, midnight
Deep pelvic endometriosis: clinical features, diagnosis, and treatment - a comprehensive review.

Deep infiltrative endometriosis (DIE) is characterized by the infiltration of endometrial tissue into the pelvic organs, such as the rectovaginal septum, utero-ovarian, and uterosacral ligaments. Bowel involvement occurs in approximately …

Published: Sept. 30, 2025, midnight
Reduced Vagal Tone in Women with Adenomyosis.

Adenomyosis is an estrogen-dependent disease featuring chronic inflammation. This study was undertaken to investigate whether the vagal tone is reduced in patients with adenomyosis as compared with healthy women. We …

Published: Sept. 30, 2025, midnight
Should patients undergo endometrioma surgery before IVF/ICSI? a retrospective study with propensity score matching.

Does surgical management of ovarian endometriomas improve in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)?

Published: Sept. 30, 2025, midnight
Relation of Endometrioma and Deep Infiltrating Endometriosis Surgery on Ovarian Reserve: A Large Single-Centre, Cross-Sectional Study.

There is a lack of reliable data or evidence-based protocol for the management of deep infiltrating endometriosis (DIE) lesions in reproductive age women. This study examines ovarian reserves in women …

Published: Sept. 30, 2025, midnight
The Translation and Cross-Cultural Adaptation of The Persian Version of The WERF EPHect Endometriosis Patient Questionnaire: A Cross-Sectional Study.

The World Endometriosis Research Foundation (WERF) Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) aims to facilitate international research on endometriosis by developing a standardized questionnaire. This study focuses on translating …

Published: Sept. 30, 2025, midnight
Saussurea lappa enhances folliculogenesis by suppressing F2-isoprostane, TNF-α, and apoptosis in endometriosis mice.

Endometriosis can disrupt folliculogenesis due to elevated levels of pro-inflammatory cytokines, free radicals, and the apoptotic response in granulosa cells (GCs). It can cause fertility issues in women. To date, …

Published: Sept. 30, 2025, midnight
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