Metabolic reprogramming in endometriosis: mechanisms and therapeutic prospects.
Endometriosis (EMS) is an estrogen-dependent chronic inflammatory disorder for which metabolic reprogramming has emerged as a central pathological feature. Driven by genetic, epigenetic, and microenvironmental stressors, ectopic endometrial cells undergo …
miR-769-5p inhibits cellular behaviors associated with endometriosis progression by directly targeting follistatin in vitro.
The pathogenesis of endometriosis (EM) remains intricate and multifactorial. This study aimed to investigate the biological functions of microRNA-769-5p (miR-769-5p) in an in vitro model of EM. Serum was obtained …
Research progress and future directions in circadian rhythms for uterine‑related diseases (Review).
Circadian rhythms are ~24 h endogenous rhythms driven by both central and peripheral clocks, with their core mechanism being a transcription‑translation feedback loop mediated by master clock genes. The present …