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BRCA2 variant linked to remote Scottish island - BioNews

BRCA2 variant linked to remote Scottish island BioNews

Published: Oct. 28, 2024, 4:39 p.m.
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Aberrant SWI/SNF Complex Members Are Predominant in Rare Ovarian Malignancies-Therapeutic Vulnerabilities in Treatment-Resistant Subtypes.

SWI/SNF (SWItch/Sucrose Non-Fermentable) is the most frequently mutated chromatin-remodelling complex in human malignancy, with over 20% of tumours having a mutation in a SWI/SNF complex member. Mutations in specific SWI/SNF …

Published: Sept. 3, 2024, midnight
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ARID1A ARID1B BAF chromatin-remodelling complex SMARCA2 SMARCA4 SWI/SNF chromatin-remodelling complex Small cell carcinoma of the ovary endometrioid ovarian cancer (EnOC) endometriosis hypercalcaemic type (SCCOHT) ovarian clear cell carcinoma (OCCC)
Genomic mutation features identify distinct BRCA-associated mutation characteristics in endometrioid carcinoma and endometrioid ovarian carcinoma.

Although endometrioid carcinoma (EC) and endometrioid ovarian carcinoma (EnOC) display similar pathological features, their molecular characteristics remain to be determined. Somatic mutation data from 2777 EC, 423 EnOC, and 57 …

Published: Nov. 27, 2021, midnight
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BRCA endometrioid carcinoma endometrioid ovarian carcinoma genome mutation immune response
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