Latest Articles

Pathogenic Properties of Human Endometriotic Epithelial Cells Require Steroid Receptor Coactivator-2.

Commonly diagnosed in reproductive-age women, endometriosis is causally linked to subfertility, infertility, and chronic pelvic pain. Although theories exist on the etiopathogenesis of endometriosis, our understanding of its cellular and …

E2F1 downregulation promotes lipid droplet accumulation and endometriosis development through impaired MGLL-mediated lipid mobilization.

Endometriosis is a common gynecological disease in which lipid metabolic dysregulation has been increasingly implicated. However, the specific metabolic changes in ectopic lesions and stromal cells remain poorly understood. It …

Paraurethral Endometrioid Carcinoma Arising From Ectopic Endometriosis: A Case Report.

Malignant transformation of endometriosis is rare and most commonly involves the ovary; transformation from paraurethral endometriosis is exceedingly rare.

Research progress on the role of IL‑37 in gynecological and obstetrics‑related diseases (Review).

Interleukin 37 (IL‑37), a member of the IL‑1 family, is recognized as an anti‑inflammatory cytokine. The anti‑inflammatory properties of recombinant human (rh)IL‑37 have been confirmed in vitro and its protective …

YTHDF3 promotes angiogenesis in endometriosis by enhancing the translation efficiency of PFKFB3.

Angiogenesis plays a critical role in the progression of endometriosis, with enhanced glycolysis accelerating pathological angiogenesis. Prior research has identified a central role for N6-methyladenosine (m6A) modification in regulating glycolytic …

Arimoclomol-loaded Pluronic F127 nanomicelles in experimental endometriosis: drug incorporation, in vitro release, and early morphological and histological responses.

Endometriosis is a chronic, estrogen-dependent inflammatory disease characterized by ectopic endometrial-like glands and stroma, persistent pelvic inflammation, pain, infertility, and frequent recurrence. The limited availability of nonhormonal and lesion-directed therapies …

Methodological Pitfalls in Endometriosis Biospecimen Research: Lessons From MAP4K4 Expression Studies.

Endometriosis is a chronic inflammatory condition affecting 10% of reproductive-age women. Current treatments remain limited and non-curative. While its biology is largely informed by human biospecimens, sample heterogeneity and methodological …

Editorial Comment to Paraurethral Endometrioid Carcinoma Arising From Ectopic Endometriosis: A Case Report.

Curcumin Alleviates Endometriosis in Sexually Mature Female Mice by Targeting PKA and Inhibiting De Novo Estrogen Synthesis.

Background: Endometriosis is an estrogen-dependent disorder with limited treatment options. The precise molecular targets of curcumin and its effects on local estrogen synthesis in this disease remain unclear. Methods: We …

Liriodendrin alleviates endometriosis via PPARγ activation and inhibition of NLRP3 inflammasome-mediated pyroptosis.

Excessive activation of inflammatory responses and oxidative stress plays a critical role in the pathophysiology of endometriosis (EMs), which is characterized by ectopic lesion growth and chronic pelvic pain. However, …