Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clinical …
The hyaluronic acid synthase (HAS) family participates in key physiological processes such as follicular development, oocyte maturation, ovulation, and embryo implantation by regulating the synthesis of hyaluronic acid, and plays …
LY01021 is a novel oral small-molecule gonadotropin-releasing hormone (GnRH) receptor antagonist intended for the treatment of various sex hormone-dependent disorders. This study aimed to evaluate the safety, tolerability, pharmacokinetics (PK), …
Endometriosis is a chronic, debilitating condition characterized by heterogenous clinical manifestations. It has a prevalence of 5-10% in women of reproductive age, and 30-50% of individuals with endometriosis are affected …
Infertility constitutes a major global health concern, affecting approximately 17.5% of couples of reproductive age. Although advances in assisted reproductive technologies (ART) have expanded treatment options, success rates remain highly …
Endometriosis is a complex disease that may affect a woman's fertility and quality of life. Owing to substantial variations in symptom severity, lesion distribution, and reproductive impact, its management presents …
From an immunological perspective, infertility mechanisms encompass not only fertilization but also implantation, as well as both early and late pregnancy loss. Growing attention is being directed towards the influence …
Endometriosis is a common, benign, chronic inflammatory disease with multiple consequences, from chronic pain to systemic comorbidities and poor quality of life. As it usually affects people of reproductive age, …
The cervicovaginal microbiome-spanning from the vagina to endometrium-remains undercharacterized in endometriosis-associated infertility. Objective: To determine whether combined vaginal and cervical microbial profiles predict frozen embryo transfer (FET) outcomes.
Endometriomas can be managed through various approaches, including careful observation, medical suppressive therapy, or surgical intervention. Malignancy is rarely a concern in women of reproductive age, making pain relief and …